Systems and methods are provided for the production of liquefied natural gas. At least one of the systems may include a plurality of compression assemblies in fluid communication with a precooler assembly. One compression assembly may be a part of a precooling loop and may include at least one compressor driven by a variable or fixed speed motor. Another compression assembly may be part of a liquefaction loop and may include at least one pair of compressors, each compressor driven by a respective turbine. The liquefaction loop may be fluidly coupled to a main heat exchanger utilized to liquefy at least a portion of a feed gas stream containing natural gas flowing through the main heat exchanger, thereby producing liquefied natural gas.