A device for sealing liquids inside a selected zone of a fluidic path that runs in a fluidic assembly and then for cutting or removing the thus sealed zone in a spillage- and contamination-free manner from said fluidic assembly. Methods of performing such contamination- and leakage-free sealing and cutting of selected fluidic path zones comprising a liquid of interest from the remaining parts of fluidic assemblies, preferably in a fully automated manner.