发明公开
- 专利标题: FGF21 VARIANTS
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申请号: EP16808969.6申请日: 2016-12-02
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公开(公告)号: EP3383890A1公开(公告)日: 2018-10-10
- 发明人: SOMMERFELD, Mark , LANGER, Thomas , BOSCHEINEN, Oliver , DREYER, Matthias , DITTRICH, Werner , HABERMANN, Paul
- 申请人: SANOFI
- 申请人地址: 54, rue La Boétie 75008 Paris FR
- 专利权人: SANOFI
- 当前专利权人: SANOFI
- 当前专利权人地址: 54, rue La Boétie 75008 Paris FR
- 代理机构: Böhmer, Thomas
- 优先权: EP15306913 20151202
- 国际公布: WO2017093465 20170608
- 主分类号: C07K14/50
- IPC分类号: C07K14/50 ; A61K38/18 ; A61K38/26 ; A61K38/28
摘要:
The present invention relates to polypeptide variants of human fibroblast growth factor 21 (FGF21) and fusion molecules thereof, as well as to nucleic acid molecules encoding the same. It further relates to their use as medicaments, in particularfor the treatment of obesity, overweight, metabolic syndrome, diabetes mellitus, hyperglycemia, dyslipidemia, non-alcoholic steatohepatitis (NASH) and/or atherosclerosis.
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