- 专利标题： MUTANT 3-HYDROXYBUTYRATE DEHYDROGENASE FROM ALCALIGENES FAECALIS AS WELL AS METHODS AND USES INVOLVING THE SAME
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申请号： EP16826037.0申请日： 2016-12-21
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公开(公告)号： EP3394252A1公开(公告)日： 2018-10-31
- 发明人: KRATZSCH, Peter , BOENITZ-DULAT, Mara , BECK, Daniela , STREIDL, Thomas , HUNT DUVALL, Stacy
- 申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH , Roche Diabetes Care GmbH
- 申请人地址： Grenzacherstraße 124 4070 Basel CH
- 专利权人： F. Hoffmann-La Roche AG,Roche Diagnostics GmbH,Roche Diabetes Care GmbH
- 当前专利权人： F. Hoffmann-La Roche AG,Roche Diagnostics GmbH,Roche Diabetes Care GmbH
- 当前专利权人地址： Grenzacherstraße 124 4070 Basel CH
- 代理机构： Teschemacher, Andrea
- 优先权： US201562270133P 20151221; EP16165421 20160414
- 国际公布： WO2017109003 20170629
- 主分类号： C12N9/04
- IPC分类号： C12N9/04
摘要：
The present disclosure relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell having the mutant 3-HBDH or the nucleic acid, and/or a method of determining the amount or concentration of 3-hydroxybutyrate in a sample. Also disclosed is the use of the mutant 3-HBDH for determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
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