The invention relates to an exhaust gas treatment system (4) and a method for regenerating such an exhaust gas treatment system. The exhaust gas treatment system comprises: an oxidation catalyst assembly (10); a particulate filter (12) arranged downstream of the oxidation catalyst assembly; a reducing agent dosing device (14) arranged downstream of the particulate filter (12); and a selective catalytic reduction device (16) arranged downstream of the reducing agent dosing device (14). The oxidation catalyst assembly (10) comprises a first oxidation catalyst (18) arranged to selectively oxidise hydrocarbons present in the exhaust stream, at least partially, with substantially no concomitant oxidation of sulfur oxides present in the exhaust stream; and a second oxidation catalyst (20) arranged downstream of the first oxidation catalyst (18), arranged to oxidise hydrocarbons or partially oxidized hydrocarbons having slipped through the first oxidation catalyst (18), as well as to concomitantly oxidise NO to NO2. The system can be fuel-effectively regenerated when running on high-sulfur fuels in order to regenerate the particulate filter (12) as well as remove sulfur species deposited on the system catalysts. The invention further relates to a vehicle comprising such an exhaust gas treatment system.