- 专利标题： SYNTHETIC OPLOPHORUS LUCIFERASES WITH ENHANCED LIGHT OUTPUT
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申请号： EP18184699.9申请日： 2010-05-03
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公开(公告)号： EP3409764A1公开(公告)日： 2018-12-05
- 发明人: Encell, Lance P. , Wood, Keith V. , Wood, Monika G. , Hall, Mary P. , Otto, Paul , Vidugiris, Gediminas , Zimmerman, Kristopher
- 申请人： Promega Corporation
- 申请人地址： 2800 Woods Hollow Road Madison, WI 53711-5399 US
- 专利权人： Promega Corporation
- 当前专利权人： Promega Corporation
- 当前专利权人地址： 2800 Woods Hollow Road Madison, WI 53711-5399 US
- 代理机构： Hoffmann Eitle
- 优先权： US174838P 20090501
- 主分类号： C12N9/02
- IPC分类号： C12N9/02 ; C12Q1/66
摘要：
The present invention discloses a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type Oplophorus luciferase and includes at least one amino acid substitution at a position corresponding to an amino acid in a wild-type Oplophorus luciferase of SEQ ID NO: 1. The modified luciferase polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the wild-type Oplophorus luciferase.
公开/授权文献
- EP3409764B1 SYNTHETIC OPLOPHORUS LUCIFERASES WITH ENHANCED LIGHT OUTPUT 公开/授权日：2020-04-15
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