- 专利标题： CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS
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申请号： EP17748126.4申请日： 2017-02-02
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公开(公告)号： EP3411045A1公开(公告)日： 2018-12-12
- 发明人: CARDELLI, James Allen , STEPHENS, Charles Albert , GRAY, Alana Lea , COLEMAN, David Thomas
- 申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
- 申请人地址： 3810 W. Lakeshore Drive Baton Rouge, LA 70808 US
- 专利权人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
- 当前专利权人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
- 当前专利权人地址： 3810 W. Lakeshore Drive Baton Rouge, LA 70808 US
- 代理机构： Karakatsanis, Georgios
- 优先权： US201662290002P 20160202
- 国际公布： WO2017136515 20170810
- 主分类号： A61K31/7048
- IPC分类号： A61K31/7048 ; A61K31/7028 ; A61K31/704
摘要：
A method of treating an activated fibroblast associated disease or pre-disease condition in a mammal comprising, administering a pharmaceutical composition including a therapeutically effective amount of a first therapeutic, wherein the first therapeutic is one of an intracellular Ca2+ elevator, a YAP / TAZ inhibitor, both a intracellular Ca2+ elevator and a YAP / TAZ inhibitor, or pharmacologically acceptable salts, solvates, esters, amides, clathrates, stereoisomers, enantiomers, prodrugs or analogs thereof, or a combination thereof.
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