- 专利标题: BISPECIFIC T CELL ENGAGING ANTIBODY CONSTRUCTS
-
申请号: EP17703379.2申请日: 2017-02-02
-
公开(公告)号: EP3411403A1公开(公告)日: 2018-12-12
- 发明人: RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
- 申请人: Amgen Research (Munich) GmbH
- 申请人地址: Staffelseestrasse 2 81477 München DE
- 专利权人: Amgen Research (Munich) GmbH
- 当前专利权人: Amgen Research (Munich) GmbH
- 当前专利权人地址: Staffelseestrasse 2 81477 München DE
- 代理机构: Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB
- 优先权: US201662290861P 20160203
- 国际公布: WO2017134140 20170810
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K16/30
摘要:
The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
信息查询