- 专利标题： METHOD TO MONITOR AND QUANTIFY INTERPHASE NUCLEAR ENVELOPE RUPTURE EVENTS
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申请号： EP17705642.1申请日： 2017-02-17
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公开(公告)号： EP3417287A1公开(公告)日： 2018-12-26
- 发明人: PIEL, Matthieu , GENTILI, Matteo , RAAB, Matthew , MANEL, Nicolas
- 申请人： Institut Curie , INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre National de la Recherche Scientifique
- 申请人地址： 26, rue d'Ulm 75248 Paris Cedex 05 FR
- 专利权人： Institut Curie,INSERM (Institut National de la Santé et de la Recherche Médicale),Centre National de la Recherche Scientifique
- 当前专利权人： Institut Curie,INSERM (Institut National de la Santé et de la Recherche Médicale),Centre National de la Recherche Scientifique
- 当前专利权人地址： 26, rue d'Ulm 75248 Paris Cedex 05 FR
- 代理机构： Cabinet Becker et Associés
- 优先权： EP16305184 20160218
- 国际公布： WO2017140875 20170824
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; G01N33/569
摘要：
The present invention provides an in vitro method for monitoring interphase nuclear envelope rupture events in a eukaryotic cell or screening or identifying compound capable of increasing or decreasing the intensity and/or frequency of interphase nuclear envelope rupture events in a eukaryotic cell. These methods relate on a protein having a cytosolic non-nuclear localization in interphase and a non-sequence specific DNA binding activity. Interphase nuclear envelope rupture events are characterized by the presence of the protein of the invention in the nucleus of the eukaryotic cell.
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