- 专利标题: SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF
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申请号: EP17769492.4申请日: 2017-03-27
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公开(公告)号: EP3434676A1公开(公告)日: 2019-01-30
- 发明人: WANG, Shulong , CHEN, Kuncheng , LIU, Xijie , HU, Yuandong , LIU, Bo , PENG, Yong , LUO, Hong , HAN, Yongxin , WANG, Shanchun , LIU, Mei , XU, Hongjiang
- 申请人: Chai Tai Tianqing Pharmaceutical Group Co., Ltd. , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
- 申请人地址: No.369 Yuzhou South Road Haizhou District Lianyungang Jiangsu 222062 CN
- 专利权人: Chai Tai Tianqing Pharmaceutical Group Co., Ltd.,Centaurus BioPharma Co., Ltd.,Lianyungang Runzhong Pharmaceutical Co., Ltd.
- 当前专利权人: Chai Tai Tianqing Pharmaceutical Group Co., Ltd.,Centaurus BioPharma Co., Ltd.,Lianyungang Runzhong Pharmaceutical Co., Ltd.
- 当前专利权人地址: No.369 Yuzhou South Road Haizhou District Lianyungang Jiangsu 222062 CN
- 代理机构: Krauss, Jan
- 优先权: CN201610180458 20160325
- 国际公布: WO2017162215 20170928
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/519 ; A61P35/00 ; A61P35/02
摘要:
The present invention belongs to the field of pharmaceutical chemistry, and relates to a substituted pyrrolopyrimidine CDK inhibitor, in particular to a compound as shown in formula I or a pharmaceutically acceptable salt or solvate thereof, as well as a preparation method thereof and a pharmaceutical composition thereof. The present invention also relates to the use of the compound and the pharmaceutical composition thereof in the preparation of a drug for treating diseases associated with CDK inhibition. The compound according to the present invention has a marked inhibitory effect on CDK, excellent drug absorption and significantly superior oral absorption effect.
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