The present invention relates to a method for producing a chiral amine, performing a transamination reaction of a prochiral amino acceptor and an amino donor in a first solution in the presence of a transaminase, thereby forming a chiral amine and a coproduct in said first solution, characterized in that said amino donor is a high molecular weight (HMW) amino donor, the molecular weight of the HMW amino donor being at least 150 g/mol; or said amino donor is affixed on a support, the total molecular weight of the amino donor and the support being at least 150 g/mol. A device for producing and separating a chiral amine is provided as well.