- 专利标题： COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS
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申请号： EP18187720.0申请日： 2011-06-02
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公开(公告)号： EP3456827A3公开(公告)日： 2019-05-08
- 发明人: Hinkle, Gregory , Kotelianski, Victor , Bettencourt, Brian , Sehgal, Alfica , Novobrantseva, Tatiana
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： 300 Third Street, 3rd Floor Cambridge, MA 02142 US
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： 300 Third Street, 3rd Floor Cambridge, MA 02142 US
- 代理机构： Hoffmann Eitle
- 优先权： US350829P 20100602; US371481P 20100806; US408271P 20101029
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/7088 ; C07K14/78 ; C07K14/47 ; C07K14/495
摘要：
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-β, and SMAD2/3 genes, and methods of using such dsRNA compositions to inhibit expression of COL1A1, TGF-β, and SMAD2/3.
公开/授权文献
- EP3456827A2 COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS 公开/授权日：2019-03-20
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