- 专利标题: FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
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申请号: EP17798743.5申请日: 2017-05-17
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公开(公告)号: EP3459948A1公开(公告)日: 2019-03-27
- 发明人: LIU, Hong , ZHOU, Yu , XIA, Wenjing , ZHANG, Dong , JIANG, Hualiang , CHEN, Kaixian
- 申请人: Shanghai Institute Of Materia Medica Chinese Academy of Sciences
- 申请人地址: No. 555 Zuchongzhi Road Zhangjiang Pudong Shanghai 201203 CN
- 专利权人: Shanghai Institute Of Materia Medica Chinese Academy of Sciences
- 当前专利权人: Shanghai Institute Of Materia Medica Chinese Academy of Sciences
- 当前专利权人地址: No. 555 Zuchongzhi Road Zhangjiang Pudong Shanghai 201203 CN
- 代理机构: dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB
- 优先权: CN201610327058 20160517
- 国际公布: WO2017198180 20171123
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; A61K31/4545 ; A61K31/437 ; A61K31/496 ; A61K31/4709 ; A61K31/506 ; A61K31/5377 ; A61P25/18 ; A61P25/22 ; A61P25/24 ; A61P25/04
摘要:
The present invention provides a fluorine-containing triazolopyridine represented by formula (I) and a racemate, R-stereoisomer, S-stereoisomer, pharmaceutically acceptable salt, or mixture thereof. The triazolopyridine can be used as a positive allosteric modulator of an mGluR2, and is highly selective in activating the mGluR2, exerting no activation or very limited activation of other homologous metabotropic glutamate receptor. The triazolopyridine can thus be used to prepare a product for treating an mGluR2-related disease, such as a central nervous system disease or neurological disease.
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