- 专利标题： WT1 ANTIGEN PEPTIDE CONJUGATE VACCINE
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申请号： EP18188307.5申请日： 2014-03-28
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公开(公告)号： EP3461493A1公开(公告)日： 2019-04-03
- 发明人: LI, Chiang Jia , BAN, Hitoshi , NISHIO, Yukihiro , GOTO, Masashi , NISHIHARA, Toshio , TAKANASHI, Yosuke
- 申请人： Sumitomo Dainippon Pharma Co., Ltd. , International Institute of Cancer Immunology, Inc.
- 申请人地址： 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8524 JP
- 专利权人： Sumitomo Dainippon Pharma Co., Ltd.,International Institute of Cancer Immunology, Inc.
- 当前专利权人： Sumitomo Dainippon Pharma Co., Ltd.,International Institute of Cancer Immunology, Inc.
- 当前专利权人地址： 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8524 JP
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： JP2013072173 20130329; JP2013158383 20130731
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61P35/00
摘要：
The present invention provides a compound represented by the formula (1):
wherein X a and Y a are each a single bond and the like,
cancer antigen peptide A is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues,
R 1 is a hydrogen atom, a group represented by the formula (2):
wherein X b and Y b are each a single bond and the like,
cancer antigen peptide B has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues, or cancer antigen peptide C, and
cancer antigen peptide C has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide or an MHC class II-restricted WT1 peptide, consisting of 7 - 30 amino acid residues containing one cysteine residue,
or a salt thereof, and the like.
wherein X a and Y a are each a single bond and the like,
cancer antigen peptide A is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues,
R 1 is a hydrogen atom, a group represented by the formula (2):
wherein X b and Y b are each a single bond and the like,
cancer antigen peptide B has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues, or cancer antigen peptide C, and
cancer antigen peptide C has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide or an MHC class II-restricted WT1 peptide, consisting of 7 - 30 amino acid residues containing one cysteine residue,
or a salt thereof, and the like.
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