- 专利标题: CYCLODEXTRIN-GRAFTED CROSS-LINKED HYALURONIC ACID COMPLEXED WITH ACTIVE DRUG SUBSTANCES AND USES THEREOF
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申请号: EP17731562.9申请日: 2017-06-20
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公开(公告)号: EP3475312A1公开(公告)日: 2019-05-01
- 发明人: EDSMAN, Katarina , BOITEAU, Jean-Guy
- 申请人: Galderma S.A.
- 申请人地址: Zugerstrasse 8 6330 Cham CH
- 专利权人: Galderma S.A.
- 当前专利权人: Galderma S.A.
- 当前专利权人地址: Zugerstrasse 8 6330 Cham CH
- 代理机构: AWA Sweden AB
- 优先权: EP16175864 20160623
- 国际公布: WO2017220622 20171228
- 主分类号: C08B37/08
- IPC分类号: C08B37/08 ; C08B37/00 ; C08B37/16 ; C08J3/075 ; C08L5/00 ; C08L5/16 ; C08L5/08 ; C07D401/14 ; A61K47/36 ; A61K47/40
摘要:
A hyaluronic acid product is comprising a cross-linked hyaluronic acid and one or more cyclodextrin molecules, and further comprising a guest molecule capable of forming a guest-host complex with the aminocyclodextrin molecule acting as a host, wherein the guest molecule is a retinoid, preferably adapalene, or a RAM BA. The hyaluronic acid is cross-linked by ether bonds, and the one or more cyclodextrin molecules are grafted onto the cross-linked hyaluronic acid by amide bonds, preferably using a triazine-based coupling reagent.
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