- 专利标题: COMBINATION COMPRISING EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR
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申请号: EP17824314.3申请日: 2017-07-06
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公开(公告)号: EP3482760A1公开(公告)日: 2019-05-15
- 发明人: YOSHIDA, Takao , SHOYAMA, Akiko , TAKANO, Hirotsugu
- 申请人: Ono Pharmaceutical Co., Ltd.
- 申请人地址: 1-5, Doshomachi 2-chome Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 专利权人: Ono Pharmaceutical Co., Ltd.
- 当前专利权人: Ono Pharmaceutical Co., Ltd.
- 当前专利权人地址: 1-5, Doshomachi 2-chome Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 代理机构: Grünecker Patent- und Rechtsanwälte PartG mbB
- 优先权: US201662359504P 20160707
- 国际公布: WO2018008711 20180111
- 主分类号: A61K31/277
- IPC分类号: A61K31/277 ; A61K45/00 ; A61P35/00 ; A61P43/00
摘要:
The present invention addresses the problem of discovering an effective cancer therapy method and providing a medicine. Provided is a medicine comprising a combination of a compound represented by general formula (I), a salt, solvate or N-oxide of the compound or a prodrug of the compound or the salt, solvate or N-oxide and an immune checkpoint inhibitor (e.g., an anti-PD-1 antibody). The combination according to the present invention exhibits a high anti-tumor effect and is therefore useful for the treatment of cancer.
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