- 专利标题: CRYSTAL FORM OF DAPAGLIFLOZIN INTERMEDIATE AND PREPARATION METHOD THEREFOR
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申请号: EP17830500.9申请日: 2017-07-21
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公开(公告)号: EP3489250A1公开(公告)日: 2019-05-29
- 发明人: LI, Xiang , YU, Jun , YU, Haizhou , WANG, Jinjia , HE, Lei , DU, Zuyin
- 申请人: Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
- 申请人地址: Economic and Technological Development Zone Lianyungang Jiangsu 222047 CN
- 专利权人: Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
- 当前专利权人: Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
- 当前专利权人地址: Economic and Technological Development Zone Lianyungang Jiangsu 222047 CN
- 代理机构: Viganò, Elena
- 优先权: CN201610587582 20160722
- 国际公布: WO2018014866 20180125
- 主分类号: C07H15/04
- IPC分类号: C07H15/04 ; C07H1/00 ; C07D309/10 ; A61P3/10
摘要:
Disclosed are a crystal form of a dapagliflozin intermediate and a preparation method therefor, and specifically disclosed are a crystal form of the dapagliflozin intermediate (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-2-ethoxy-6-(methylhydroxyl) tetrahydro-2H-pyran-3,4,5-triol and a preparation method therefor. The advantages thereof lie in that an intermediate can be highly purified to obtain a sample with a purity of 99.3% or more, wherein same has an important significance for improving the quality of the dapagliflozin, and the preparation process is simple and suitable for industrial production.
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