- 专利标题： MUTANT INTERLEUKIN-2 POLYPEPTIDES
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申请号： EP18191941.6申请日： 2012-02-07
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公开(公告)号： EP3489255A1公开(公告)日： 2019-05-29
- 发明人: AST, Oliver , BRUENKER, Peter , FREIMOSER-GRUNDSCHOBER, Anne , HERTER, Sylvia , HOFER, Thomas U. , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , NICOLINI, Valeria G. , UMANA, Pablo
- 申请人： Roche Glycart AG
- 申请人地址： Wagistrasse 10 8952 Schlieren CH
- 专利权人： Roche Glycart AG
- 当前专利权人： Roche Glycart AG
- 当前专利权人地址： Wagistrasse 10 8952 Schlieren CH
- 代理机构： Kaschau, Nikolai Elias
- 优先权： EP11153964 20110210; EP11164237 20110429
- 主分类号： C07K14/55
- IPC分类号： C07K14/55 ; C12N15/26 ; A61K39/395 ; C07K16/46 ; C07K19/00 ; C07K14/54 ; A61K38/20 ; C07K16/28 ; C07K16/30 ; C07K16/40 ; A61K39/00 ; A61K47/68
摘要：
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
公开/授权文献
- EP3489255B1 MUTANT INTERLEUKIN-2 POLYPEPTIDES 公开/授权日：2021-06-16
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