In a to-be-cooled body protection structure of a saddle-ridden vehicle, a guard member (48) protects at least a front portion of a to-be-cooled body requiring cooling with a travelling air, straddles over a pair of left and right frame members, is supported to the body frame, and located at a rear of a front wheel. A plurality of through-holes (61, 62, 63, 64, 65, 66) are provided on the guard member, each include at least one linear edge portion linearly extending, and are formed into non-circular shapes. The non-circular through-holes are arranged such that linear ribs (70, 71, 72, 73, 74) are formed between linear edge portions, as said linear edge portion, facing each other of adjacent ones of the non-circular through-holes. Accordingly, while protecting the to-be-cooled body from a small stone etc. jumped up by the front wheel, a larger amount of travelling air is guided to the to-be-cooled body side.