The embodiments of the invention disclose a data encapsulation and transmission methods, a device, and a computer storage medium. The data encapsulation method comprises: encapsulating, according to a CPRI line bit rate at a receiving terminal and using FTN encapsulation, a frame corresponding to CPRI to be a block frame combination comprising at least block frame, wherein each block frame comprises 256 words, and each word comprises a frame overhead byte and a frame payload byte.