Systems, methods, apparatus (100), and articles of manufacture are disclosed to generate an integrated modular architecture (IMA) model. An example apparatus (100) includes an interface importer (430) to import first IMA protocol definitions (540) into a computer modeling environment to generate libraries (550) and generate IMA model objects (780), a model object handler (450) to import ones of IMA model objects (780) into the computer modeling environment to generate a first IMA model (704) corresponding to an aircraft system (106) of an aircraft (108) and generate an IMA system model (754) corresponding to the aircraft (108) by generating IMA models (702) including the first IMA model (704). The example apparatus (100) further includes an interface validator (480) to validate the IMA system model (754) by comparing an output of the IMA system model (754) to a validation output, an interface exporter (440) to generate manufacturing build instructions (124) of the aircraft system (106) when the IMA system model (754) is validated, and a report generator (490) to initiate production of the aircraft system (106).