- 专利标题： PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE
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申请号： EP19188774.4申请日： 2013-05-22
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公开(公告)号： EP3581571A1公开(公告)日： 2019-12-18
- 发明人: BARBUGIAN, Natale Alvaro , FORINO, Romualdo , FUMAGALLI, Tiziano , ORSINI, Paolo
- 申请人： Nerviano Medical Sciences S.r.l.
- 申请人地址： Viale Pasteur, 10 20014 Nerviano (MI) IT
- 专利权人： Nerviano Medical Sciences S.r.l.
- 当前专利权人： Nerviano Medical Sciences S.r.l.
- 当前专利权人地址： Viale Pasteur, 10 20014 Nerviano (MI) IT
- 优先权： EP12169139 20120523
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; A61K31/496 ; A61P35/00
摘要：
The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention
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