- 专利标题： SYNTHESIS OF A COMPOUND THAT MODULATES KINASES
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申请号： EP19189460.9申请日： 2016-05-05
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公开(公告)号： EP3581573A1公开(公告)日： 2019-12-18
- 发明人: IBRAHIM, Prabha N. , JIN, Masayoshi , MATSUURA, Shinji
- 申请人： Plexxikon Inc. , Daiichi Sankyo Company, Limited
- 申请人地址： 91 Bolivar Drive, Suite A Berkeley, CA 94710 US
- 专利权人： Plexxikon Inc.,Daiichi Sankyo Company, Limited
- 当前专利权人： Plexxikon Inc.,Daiichi Sankyo Company, Limited
- 当前专利权人地址： 91 Bolivar Drive, Suite A Berkeley, CA 94710 US
- 代理机构： Wallace, Sheila Jane
- 优先权： US201562157902P 20150506; US201562241040P 20151013
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P35/00
摘要：
The present disclosure provides a process for the preparation of crystalline Form C of Compound II:
comprising:
(1) adding Compound II to from about 0.4% v/v wet methyl tert-butyl ether (MTBE) to about 1.5% v/v wet MTBE to provide a reaction mixture;
(2) refluxing the reaction mixture;
(3) cooling the reaction mixture to about room temperature; and
(4) isolating the crystalline Form C of Compound II from the reaction mixture.
comprising:
(1) adding Compound II to from about 0.4% v/v wet methyl tert-butyl ether (MTBE) to about 1.5% v/v wet MTBE to provide a reaction mixture;
(2) refluxing the reaction mixture;
(3) cooling the reaction mixture to about room temperature; and
(4) isolating the crystalline Form C of Compound II from the reaction mixture.
公开/授权文献
- EP3581573B1 SYNTHESIS OF A COMPOUND THAT MODULATES KINASES 公开/授权日：2022-07-06
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