发明公开
- 专利标题: CRYSTAL OF TRICYCLIC COMPOUND
-
申请号: EP18845759.2申请日: 2018-08-17
-
公开(公告)号: EP3670518A1公开(公告)日: 2020-06-24
- 发明人: LIU, Shilan , WANG, Dahai , LIANG, Guibai , WANG, Honglin , HU, Guoping , LI, Jian , CHEN, Shuhui
- 申请人: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- 申请人地址: No. 369 Yuzhou South Road Haizhou District Lianyungang, Jiangsu 222062 CN
- 专利权人: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- 当前专利权人: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- 当前专利权人地址: No. 369 Yuzhou South Road Haizhou District Lianyungang, Jiangsu 222062 CN
- 代理机构: Müller Schupfner & Partner Patent- und Rechtsanwaltspartnerschaft mbB
- 优先权: CN201710714247 20170818
- 国际公布: WO2019034139 20190221
- 主分类号: C07D495/14
- IPC分类号: C07D495/14 ; A61P37/06
摘要:
The present application relates to a crystal of a tricyclic compound, in particular to a crystal of (S)-8-(4,4-difluorocyclohexyl)-8H-thieno[3,4]pyrrolo[1,5-a]imidazole, a preparation method therefor, a crystal composition and a pharmaceutical composition thereof and the use thereof. The X-ray powder diffraction spectrum of the crystal of the compound of formula I in the present application, represented by a 2-θ value, has a diffraction peak at about 11.49°, 15.05°, 20.14°, 21.53° or 21.79°. The crystal of the compound of formula I in the present application has excellent physical properties, high safety and metabolic stability, and has a good inhibitory effect on IDO and a high medicinal value
信息查询