- 专利标题： ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
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申请号： EP20152702.5申请日： 2013-12-12
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公开(公告)号： EP3705490A1公开(公告)日： 2020-09-09
- 发明人: ZHANG, Feng , RAN, Fei , SHALEM, Ophir
- 申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College
- 申请人地址： 415 Main Street Cambridge, MA 02142 US
- 专利权人： The Broad Institute, Inc.,Massachusetts Institute of Technology,President and Fellows of Harvard College
- 当前专利权人： The Broad Institute, Inc.,Massachusetts Institute of Technology,President and Fellows of Harvard College
- 当前专利权人地址： 415 Main Street Cambridge, MA 02142 US
- 代理机构： Icely, Dominic Michael
- 优先权： US201261736527P 20121212; US201361748427P 20130102; US201361758468P 20130130; US201361769046P 20130225; US201361802174P 20130315; US201361791409P 20130315; US201361806375P 20130328; US201361814263P 20130420; US201361819803P 20130506; US201361828130P 20130528; US201361835931P 20130617; US201361836101P 20130617
- 主分类号： C07K14/44
- IPC分类号： C07K14/44
摘要：
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.
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