- 专利标题： DIAGNOSIS AND THERAPY OF CANCER INVOLVING CANCER STEM CELLS
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申请号： EP20181374.8申请日： 2014-07-30
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公开(公告)号： EP3738612A1公开(公告)日： 2020-11-18
- 发明人: SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
- 申请人： Biontech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 申请人地址： An der Goldgrube 12 55131 Mainz DE
- 专利权人： Biontech AG,Astellas Pharma Inc.,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人： Biontech AG,Astellas Pharma Inc.,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人地址： An der Goldgrube 12 55131 Mainz DE
- 代理机构： Schnappauf, Georg
- 优先权： PCT/EP2013/002272 20130731
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/50 ; G01N33/569 ; G01N33/574
摘要：
The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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