Systems, methods, and instrumentalities are disclosed for multiple resource unit (RU) allocation for OFDMA WLAN. A transmitter may parse an encoded bit stream into a plurality of spatial streams. The transmitter may determine an allocation of encoded bits of the plurality of spatial streams to a plurality of interleavers. The transmitter may allocate the encoded bits to the plurality of interleavers based on the determined allocation. The allocation of the encoded bits may be determined based on one or more of channel related feedback, an RU configuration associated with the transmission, a quality of service (QoS), and/or traffic priorities. The transmitter may interleave the encoded bits using the plurality of interleavers. The transmitter may combine the interleaved encoded bits from the plurality of interleavers into a sequenced bit stream.