- 专利标题： DEGRADABLE POLYETHYLENE GLYCOL CONJUGATE
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申请号： EP19776122.4申请日： 2019-03-29
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公开(公告)号： EP3778628A1公开(公告)日： 2021-02-17
- 发明人: YOSHIOKA, Hiroki , KAMIYA, Masaki , YAMAMOTO, Yuji , HIRAI, Midori , SASAKI, Akiko , NISHIYAMA, Nobuhiro , MATSUI, Makoto , TAKEMOTO, Hiroyasu , MIYAUCHI, Kazuki , NOMOTO, Takahiro , TOMODA, Keishiro
- 申请人： NOF Corporation , Tokyo Institute of Technology
- 申请人地址： JP Shibuya-ku Tokyo 150-6019 20-3 Ebisu 4-chome; JP Tokyo 152-8550 2-12-1, Ookayama Meguro-ku
- 代理机构： J A Kemp LLP
- 优先权： JP2018064306 20180329
- 国际公布： WO2019189853 20191003
- 主分类号： C07K14/585
- IPC分类号： C07K14/585 ; A61K47/60 ; A61P43/00 ; C07K5/06 ; C07K5/08 ; C07K5/10 ; C07K7/06 ; C07K14/535 ; C07K14/61 ; C08G65/329
摘要：
Provided is a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells.
A bio-related substance bonded to a degradable polyethylene glycol derivative, and represented by the following formula (A):
wherein m is 1 - 7, n1 and n2 are each independently 45 - 682, p is 1 - 4, R is an alkyl group having 1 - 4 carbon atoms, Z is an oligopeptide with 2 - 8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2 - 5 active hydrogens, D is the bio-related substance, L 1 , L 2 , L 3 , L 4 and L 5 are each independently a single bond or a divalent spacer, and y is 1 - 40.
A bio-related substance bonded to a degradable polyethylene glycol derivative, and represented by the following formula (A):
wherein m is 1 - 7, n1 and n2 are each independently 45 - 682, p is 1 - 4, R is an alkyl group having 1 - 4 carbon atoms, Z is an oligopeptide with 2 - 8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2 - 5 active hydrogens, D is the bio-related substance, L 1 , L 2 , L 3 , L 4 and L 5 are each independently a single bond or a divalent spacer, and y is 1 - 40.
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