- 专利标题： FUSED-CYCLIC PYRAZOLONE FORMAMIDE COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
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申请号： EP19806732.4申请日： 2019-05-21
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公开(公告)号： EP3798218A1公开(公告)日： 2021-03-31
- 发明人: LIU, Hong , GENG, Meiyu , ZHOU, Yu , DING, Jian , FANG, Feifei , AI, Jing , LI, Jian , PENG, Xia , JIANG, Hualiang , JI, Yinchun , CHEN, Kaixian
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： CN Pudong, Shanghai 201203 555 Zu Chong Zhi Road Zhang Jiang
- 代理机构： Lavoix
- 优先权： CN201810491115 20180521
- 国际公布： WO2019223704 20191128
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D453/04 ; C07D487/04 ; A61K31/437 ; A61K31/519 ; A61K31/5025 ; A61K31/4985 ; A61K31/4709 ; A61P35/00
摘要：
Provided are a class of fused-cyclic pyrazolone formamide compounds and a preparation method therefor, a pharmaceutical composition and the use thereof. Specifically, provided is a compound having the structure as shown in formula (I) (with each group defined in the description). The compound can be used as an AXL inhibitor in the preparation of a pharmaceutical composition for treating tumors.
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