发明公开
- 专利标题： CRYSTALLINE SYNTHETIC INTERMEDIATE USEFUL IN PROCESSES FOR MAKING A MDM2 INHIBITOR
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申请号： EP20197741.0申请日： 2014-06-09
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公开(公告)号： EP3805232A1公开(公告)日： 2021-04-14
- 发明人: Bio, Matthew , Caille, Sebastian , Cochran, Brian , Fang, Yuanqing , Fox, Brian Matthew , Lucas, Brian , McGee, Lawrence R. , Vounatsos, Filisaty , Wiedemann, Sean , Wortman, Sarah
- 申请人： Amgen Inc.
- 申请人地址： US Thousand Oaks, CA 91320-1799 One Amgen Center Drive
- 代理机构： Hoffmann Eitle
- 优先权： US201361833196 P 20130610
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07C309/35
摘要：
The present invention provides the crystalline form of an intermediate useful in processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as processes for making the intermediate.
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