- 专利标题： ANTIBODY THAT BINDS ERBB-2 AND ERBB-3
-
申请号： EP20191815.8申请日： 2015-02-27
-
公开(公告)号： EP3805268A1公开(公告)日： 2021-04-14
- 发明人: GEUIJEN, Cecilia Anna Wilhelmina , DE KRUIF, Cornelis Adriaan , THROSBY, Mark , LOGTENBERG, Ton , BAKKER, Alexander Berthold Hendrik
- 申请人： Merus N.V.
- 申请人地址： NL 3584 CM Utrecht Yalelaan 62
- 代理机构： V.O.
- 优先权： EP14167066 20140505
- 主分类号： C07K16/32
- IPC分类号： C07K16/32 ; A61P9/04 ; A61P35/00 ; A61P35/04 ; A61P43/00
摘要：
The invention relates among others to antibodies comprising a first antigen-binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB-3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.
信息查询
