- 专利标题： CRYSTALLINE FORM OF A N-(PYRAZOL-4-YL)SULFONYL-6-(PYRAZOL-1-YL)-2-(PYRROLIDIN-1-YL)PYRIDINE-3-CARBOXAMIDE FOR TREATING CYSTIC FIBROSIS
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申请号： EP20199562.8申请日： 2017-12-08
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公开(公告)号： EP3812379A1公开(公告)日： 2021-04-28
- 发明人: ABELA, Alexander Russell , ALCACIO, Timothy , ANDERSON, Corey , ANGELL, Paul Timothy , BAEK, Minson , CLEMENS, Jeremy J. , CLEVELAND, Thomas , FERRIS, Lori Ann , GROOTENHUIS, Peter Diederik Jan , GROSS, Raymond Stanley , GULEVICH, Anton , HADIDA RUAH, Sara Sabina , HSIA, Clara Kuang-Ju , HUGHES, Robert M. , JOSHI, Pramod Virupax , KANG, Ping , KESHAVARZ-SHOKRI, Ali , KHATUYA, Haripada , KRENITSKY, Paul John , MCCARTNEY, Jason , MILLER, Mark Thomas , PARASELLI, Prasuna , PIERRE, Fabrice Jean Denis , SHI, Yi , SHRESTHA, Muna , SIESEL, David Andrew , STAVROPOULOS, Kathy , TERMIN, Andreas P. , UY, Johnny , VAN GOOR, Fredrick F. , YOUNG, Timothy John , ZHOU, Jinglan
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US Boston, MA 02210 50 Northern Avenue
- 代理机构： Oates, Edward Christopher
- 优先权： US201662432537 P 20161209
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/455 ; A61P11/00
摘要：
Compounds of Formula (I):
pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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