The invention relates to the fields of immunology, oncology, and more specifically, to antibodies that can be used in the treatment of various cancers, more particularly cancers expressing CD117 antigen. These antibodies or antigen-binding molecules may be monoclonal antibodies or binding fragments thereof, they may be in particular chimeric or humanized. These antibodies may be antagonistic. The invention also relates to anticancerous or pharmaceutical compositions containing an antibody according to this invention and methods of use of these, either for laboratory work or for medical treatment.