发明公开
- 专利标题: ANTI-HUMAN NOROVIRUS AGENT
-
申请号: EP19905829.8申请日: 2019-12-27
-
公开(公告)号: EP3903791A1公开(公告)日: 2021-11-03
- 发明人: KATAYAMA Kazuhiko , FUJIMOTO Akira , HAGA Kei , TODAKA Reiko , SATO Toshiro
- 申请人: Keio University , The Kitasato Institute
- 申请人地址: JP Tokyo, 108-8345 15-45, Mita 2-chome, Minato-ku,; JP Tokyo 108-8641 9-1, Shirokane 5-chome Minato-ku
- 代理机构: Henkel & Partner mbB
- 优先权: JP2018244213 20181227
- 国际公布: WO2020138447 20200702
- 主分类号: A61K31/7004
- IPC分类号: A61K31/7004 ; A61K31/7024 ; A61P31/14
摘要:
An object of the present invention is to provide an anti-human norovirus agent which can inhibit infection with and proliferation of human norovirus. The present inventors have found that the object can be attained through provision of an anti-human norovirus agent comprising, as an active ingredient, a fucose analog having an inhibitory action on glycosylation by fucosyltransferase (FUT). Examples of the active ingredient include a fucose analog represented by formula (III) or (IV) or a salt thereof.
[In the formulas, each of formula (III) and formula (IV) represents an α-anomer or a β-anomer; each of R 1 , R 3 , and R 4 is -OH or -OAc; R 2 is a halogen atom, -OH, or -OAc; and R 5 is -CH 3 , -C=CH, -C≡CCH 3 , or -CH 2 C≡CH.]
[In the formulas, each of formula (III) and formula (IV) represents an α-anomer or a β-anomer; each of R 1 , R 3 , and R 4 is -OH or -OAc; R 2 is a halogen atom, -OH, or -OAc; and R 5 is -CH 3 , -C=CH, -C≡CCH 3 , or -CH 2 C≡CH.]
信息查询