发明公开
- 专利标题： CONSENSUS PROSTATE ANTIGENS, NUCLEIC ACID MOLECULES ENCODING THE SAME AND USES THEREOF
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申请号： EP21175561.6申请日： 2011-11-14
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公开(公告)号： EP3909973A3公开(公告)日： 2022-01-26
- 发明人: WEINER, David, B. , YAN, Jian , FERRARO, Bernadette , SARDESAI, Niranjan, Y. , RAMANATHAN, Mathura, P.
- 申请人： The Trustees of The University of Pennsylvania , Inovio Pharmaceuticals, Inc.
- 申请人地址： US Philadelphia, PA 19104 3160 Chestnut Street Suite 200; US Plymouth Meeting, PA 19462 660 W. Germantown Pike Suite 110
- 代理机构： Leonard, Thomas Charles
- 优先权： US41781710 P 20101129
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K39/00
摘要：
Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
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