- 专利标题： LEVODOPA DERIVATIVE AND USE THEREOF
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申请号： EP20756575.5申请日： 2020-02-06
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公开(公告)号： EP3925624A1公开(公告)日： 2021-12-22
- 发明人: NAGASAKI, Yukio , SATO, Yuna , VONG, Binh Long , CHONPATHOMPIKUNLERT, Pennapa , HUTAMEKALIN, Pilaiwanwadee , TAKAHASHI, Reita
- 申请人： University of Tsukuba
- 申请人地址： JP Ibaraki 305-8577 1-1-1, Tennodai Tsukuba-shi
- 代理机构： Beckmann, Claus
- 优先权： JP2019022895 20190212
- 国际公布： WO2020166473 20200820
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61P25/16 ; A61P43/00 ; C08G65/333 ; C08G69/40 ; A61K9/127 ; A61K47/60 ; A61K31/198
摘要：
[Object]
To provide a drug that can mitigate shortcomings, such as low retention in blood, associated with L-DOPA in treating Parkinson's disease.
[Solution]
Incorporation of L-DOPA into a carrier in a form of a block copolymer (PEG-b-poly(3,4-hydroxy-protected L-DOPA)) significantly improves the retention of the agent in the blood.
To provide a drug that can mitigate shortcomings, such as low retention in blood, associated with L-DOPA in treating Parkinson's disease.
[Solution]
Incorporation of L-DOPA into a carrier in a form of a block copolymer (PEG-b-poly(3,4-hydroxy-protected L-DOPA)) significantly improves the retention of the agent in the blood.
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