Systems and methods for dynamic optical interferometer locking using entangled photons are provided. In certain embodiments, a system includes an optical source for generating a pair of photons. Also, the system includes first and second emitter/receivers that emit first and second photons towards first and second remote reflectors and receive reflected first and second photons along first and second optical paths. Additionally, the system includes a mode combiner for combining the reflected first photon and second photon into a first and second output port. Moreover, the system includes a coarse adjuster that performs coarse adjustments and a fine adjuster that performs fine adjustments to the first and second optical paths. Further, the system includes a plurality of photodetectors that detect photons from the first and second output ports. Additionally, the system includes a processor that controls the coarse and fine adjustments based on received signals from the photodetectors.