发明公开
- 专利标题： 6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
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申请号： EP21196697.3申请日： 2016-04-22
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公开(公告)号： EP3957627A1公开(公告)日： 2022-02-23
- 发明人: Tanaka, Satoru , Ogawa, Tomoyuki , Kai, Hiroyuki , Ogata, Yuki , Hirai, Keiichiro , Kurose, Noriyuki , Fujii, Yasuhiko
- 申请人： Shionogi & Co., Ltd
- 申请人地址： JP Osaka-shi, Osaka 541-0045 1-8, Doshomachi 3-chome Chuo-ku
- 代理机构： Boult Wade Tennant LLP
- 优先权： JP2015127214 20150625
- 主分类号： C07D213/69
- IPC分类号： C07D213/69 ; A61K31/4412 ; A61K31/505 ; A61K31/506 ; A61K31/53 ; A61K31/5377 ; A61P1/02 ; A61P1/04 ; A61P1/16 ; A61P1/18 ; A61P3/10 ; A61P9/10 ; A61P11/00 ; A61P11/06 ; A61P11/08 ; A61P13/00 ; A61P13/08 ; A61P13/10 ; A61P13/12 ; A61P17/02
摘要：
A compound for use as P2X7 antagonist represented by Formula (I):
wherein
or the like
Y 1 is O or the like; Z 1 is C(R 4 ) or N; Z 2a is C(R 5a ) or the like; Z 3a is C(R 6 ) or the like;
R 4 , R 5a and R 6 are each independently a hydrogen atom or the like; R 1 is substituted or unsubstituted aromatic carbocyclyl or the like; R 2a , R 2b , R 2c and R 2d are each independently a hydrogen atom or the like; X is N(R 7a ) or the like; R 7a is a hydrogen atom or the like; R 3 is
or the like
Ring B is a 6-membered aromatic carbocycle or the like; R 9a and R 10a are each independently halogen or the like; n is an integer from 1 to 5; m is an integer from 0 to 4; and p1 is an integer from 0 to 3,
or a pharmaceutically acceptable salt thereof.
wherein
or the like
Y 1 is O or the like; Z 1 is C(R 4 ) or N; Z 2a is C(R 5a ) or the like; Z 3a is C(R 6 ) or the like;
R 4 , R 5a and R 6 are each independently a hydrogen atom or the like; R 1 is substituted or unsubstituted aromatic carbocyclyl or the like; R 2a , R 2b , R 2c and R 2d are each independently a hydrogen atom or the like; X is N(R 7a ) or the like; R 7a is a hydrogen atom or the like; R 3 is
or the like
Ring B is a 6-membered aromatic carbocycle or the like; R 9a and R 10a are each independently halogen or the like; n is an integer from 1 to 5; m is an integer from 0 to 4; and p1 is an integer from 0 to 3,
or a pharmaceutically acceptable salt thereof.
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