发明公开
- 专利标题： ISOQUINOLINONE DERIVATIVES SERVING AS ROCK PROTEIN KINASE INHIBITORS AND USE THEREOF
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申请号： EP20827811.9申请日： 2020-06-22
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公开(公告)号： EP3988544A1公开(公告)日： 2022-04-27
- 发明人: LIU, Yizhi , WANG, Yandong , WU, Lingyun , YOU, Xu , XIAO, Zheming , CHEN, Shuhui
- 申请人： Guangzhou Ocusun Ophthalmic Biotechnology Co., Ltd.
- 申请人地址： CN Guangdong 510627 Room 1108, 11/F, Tower A R&F Winner Plaza No. 100 West Huangpu Road Tianhe District Guangzhou
- 代理机构： Latscha Schöllhorn Partner AG
- 优先权： CN201911078066 20191106
- 国际公布： WO2020253882 20201224
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; A61K31/551 ; A61P7/02 ; A61P9/10 ; A61P9/08 ; A61P27/06 ; A61P9/12
摘要：
Disclosed are a series of isoquinolone derivatives as ROCK protein kinase inhibitors and uses thereof in preparing medicaments for ROCK protein kinase inhibitor-related glaucoma or ocular hypertension diseases. Specially, disclosed are a compound of formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.
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