- 专利标题： TRANS-SPLICING RIBOZYME SPECIFIC TO APOE4 RNA AND USE THEREOF
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申请号： EP21760156.6申请日： 2021-02-26
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公开(公告)号： EP3992292A1公开(公告)日： 2022-05-04
- 发明人: LEE, Seong-Wook , HAN, Seung Ryul
- 申请人： RZNOMICS INC.
- 申请人地址： KR Yongin-si, Gyeonggi-do 16890 327, Software ICT Building Dankook University 152, Jukjeon-ro Suji-gu
- 代理机构： De Clercq & Partners
- 优先权： KR20210025822 20210225
- 国际公布： WO2021172925 20210902
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K48/00 ; A61K31/7105 ; A61P25/28
摘要：
The present invention relates to a trans-splicing ribozyme specific to Alzheimer's disease, and a use thereof. The trans-splicing ribozyme replaces RNA of genes that cause or increase the risk of Alzheimer's disease with RNA of genes that are beneficial for the treatment of the disease, thereby reducing the expression of the disease-causing genes and increasing the expression of the genes beneficial for the treatment of the disease, and thus can be usefully used to prevent or treat Alzheimer's disease.
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