- 专利标题: RACEMIC PREPARATION METHOD FOR CHIRAL BETA-AMINO ACID AND DERIVATIVE THEREOF
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申请号: EP20848133.3申请日: 2020-06-08
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公开(公告)号: EP4008712A1公开(公告)日: 2022-06-08
- 发明人: LI, Hongliang , ZHANG, Xianyi , GAO, Zhaobo , MEI, Yijiang
- 申请人: Zhejiang Jiuzhou Pharmaceutical Co., Ltd
- 申请人地址: CN Taizhou City, Zhejiang 318000 99 Waisha Road Jiaojiang District
- 代理机构: IPrime Bonnekamp Sparing Patentanwaltsgesellschaft mbH
- 优先权: CN201910705432 20190801
- 国际公布: WO2021017645 20210204
- 主分类号: C07C227/36
- IPC分类号: C07C227/36 ; C07C231/12 ; C07D241/08 ; C07D295/185 ; C07D471/04 ; C07D487/04 ; C07C229/34 ; C07C233/47 ; C07C229/12 ; C07C229/18 ; C07B55/00
摘要:
The present disclosure relates to the field of medicine synthesis, and relates to a method for a racemic preparation of chiral β -amino acids and derivatives thereof, and in particular to a method for racemizing sitagliptin intermediates.
where R 1 is hydrogen, alkyl or aryl; R 2 is hydrogen, alkyl or aryl; R 3 is hydrogen, alkyl, aryl or acyl; R 4 is alkyl, aryl, OR', SR', NHR' or NR'R", wherein R', R" are hydrogen, alkyl or aryl.
where R 1 is hydrogen, alkyl or aryl; R 2 is hydrogen, alkyl or aryl; R 3 is hydrogen, alkyl, aryl or acyl; R 4 is alkyl, aryl, OR', SR', NHR' or NR'R", wherein R', R" are hydrogen, alkyl or aryl.
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