A method for intelligently preventing and handling indoor air pollution is adapted to be implemented in an indoor space (A) and includes providing a cloud processing device (5) to receive and intelligently compare an outdoor gas detection data, an indoor gas detection data, and device gas detection data with each other. Then, the cloud processing device (5) remotely transmits a control signal to the communication relay station (4) and further to an indoor gas exchange system (2), so that the indoor gas exchange system (2) is capable of intelligently enabling the gas processing device and controlling the operation time of the gas processing device for exchanging a polluted gas in the indoor space (A) with the outdoor gas. Moreover, the gas exchanger (21) can perform purification for the polluted gas at the location of the gas exchanger (21), thereby allowing the polluted gas in the indoor space (A) to be exchanged into a clean, safe, and breathable gas.