- 专利标题： MELANOCORTIN-4 RECEPTOR AGONISTS FOR THE TREATMENT OF DISORDERS CHARACTERISED BY POMC GENE HYPERMETHYLATION
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申请号： EP21204226.1申请日： 2016-09-29
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公开(公告)号： EP4029513A1公开(公告)日： 2022-07-20
- 发明人: VAN DER PLOEG, Leonardus, H.T. , HENDERSON, Bart , KUHNEN, Peter
- 申请人： Rhythm Pharmaceuticals, Inc. , Charité - Universitätsmedizin Berlin
- 申请人地址： US Boston, MA 02116 222 Berkeley Street, 12th floor; DE 10117 Berlin Charitéplatz 1
- 代理机构： J A Kemp LLP
- 优先权： US201562235003 P 20150930
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61P3/04
摘要：
The disclosure is related to a method of treating a disorder, such as Prader Willi Syndrome (PWS), obesity or hyperphagia, in a subject using a melanocortin-4 receptor (MC4R) agonist. Also described is method of treating a subject having a deficiency in the pro-opiomelanocortin (POMC)-MC4R pathway, such as a POMC-null or a PCSK-null subject, using a MC4R agonist.
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