发明公开
- 专利标题： IMMUNOCYTOKINE COMPRISING HETERODIMERIC PROTEIN COMPLEX BASED ON IL-15/IL-15R ALPHA
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申请号： EP20865705.6申请日： 2020-09-20
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公开(公告)号： EP4032539A1公开(公告)日： 2022-07-27
- 发明人: ULITIN, Andrei Borisovich , KONONOV, Aleksey Vladimirovich , AGEEV, Sergei Andreevich , GORDEEV, Aleksandr Andreevich , VINOGRADOVA, Elena Vladimirovna , EVDOKIMOV, Stanislav Rudolfovich , SHMAKOVA, Aleksandra Pavlovna , MITROSHIN, Ivan Vladimirovich , MOROZOV, Dmitry Valentinovich
- 申请人： Joint Stock Company "Biocad"
- 申请人地址： RU St.Petersburg 198515 Liter A bld. 34 ul. Svyazi Strelna Petrodvortsoviy District
- 代理机构： Held, Stephan
- 优先权： RU2019129569 20190919
- 国际公布： WO2021054867 20210325
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A61K39/395 ; A61P35/00 ; C07K14/54 ; C07K14/715 ; C07K16/28 ; C07K19/00 ; C12N15/13 ; C12N15/24 ; C12N15/62
摘要：
The present invention relates to an immunocytokine comprising an heterodimeric protein complex based on IL-15/IL-15Rα, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease. The present invention further relates to an immunocytokine comprising a heterodimeric protein complex based on an IL-15/IL-15Rα and an immunomodulatory antibody, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease.
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