- 专利标题： ANTI-CD3 ANTIBODIES, ANTI-CD123 ANTIBODIES AND BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO CD3 AND/OR CD123
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申请号： EP22152787.2申请日： 2016-01-22
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公开(公告)号： EP4039710A2公开(公告)日： 2022-08-10
- 发明人: ALBRECHT, Jana , BARRIERE, Cédric , BEIL, Christian , BENINGA, Jochen , CARREZ, Chantal , GUERIF, Stéphane , KROLL, Katja , LANGE, Christian , LEMOINE, Cendrine , LEUSCHNER, Wulf-Dirk , RAO, Ercole , SCHNEIDER, Marion , WETZEL, Marie-Cécile , WONEROW, Peter
- 申请人： SANOFI
- 申请人地址： FR 75008 Paris 54 rue La Boétie
- 代理机构： Lavoix
- 优先权： EP15305077 20150123
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/00 ; A61P35/00 ; A61P35/02
摘要：
The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.
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