- 专利标题： RECOMBINANT TERT-ENCODING VIRAL GENOMES AND VECTORS
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申请号： EP21382441.0申请日： 2021-05-12
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公开(公告)号： EP4089171A1公开(公告)日： 2022-11-16
- 发明人: BLASCO, Maria , MARTINEZ, Paula , BOSCH TUBERT, Maria Fàtima , JIMENEZ CENZANO, Verónica , GARCIA MARTINEZ, Miquel , CASANA LORENTE, Estefanía
- 申请人： Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) , Universitat Autònoma de Barcelona
- 申请人地址： ES 28029 Madrid C/ Melchor Fernández Almagro, 3; ES 08193 Cerdanyola del Vallès Edifici A - Campus de la UAB s/n
- 代理机构： Hoffmann Eitle
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N15/861 ; A61K48/00
摘要：
Described herein are recombinant viral genomes comprising a nucleotide sequence encoding a telomerase reverse transcriptase (TERT) operably linked to a tissue-specific and/or organ-specific promoter. Aspects described herein may be used in the treatment of conditions associated with shortened telomere length, such as pulmonary fibrosis, myocardial infarction and conditions associated therewith.
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