The invention relates to a double-stranded ribonucleic acid (dsRNA) agent for inhibiting expression of Angiopoietin-like 3 (ANGPTL3), comprising a sense strand and an antisense strand forming a duplex region, wherein the sense strand comprises at least 15, preferably at least 16 and most preferably at least 17 contiguous nucleotides of the nucleotide sequence 5' -GUCUCAAAAUGGAAGGUUAUA- 3 ' (SEQ ID NO: 1160) , wherein the antisense strand comprises at least 15 contiguous nucleotides of the nucleotide sequence 5' -UAUAACCUUCCAUUUUGAGACUU-3' (SEQ ID NO: 1341) , wherein at least one of the modified nucleotides is selected from the group consisting of a 2'-O- methyl modified nucleotide, a 2 '-fluoro modified nucleotide, and a nucleotide comprising a 5'-phosphorothioate group, and wherein a ligand comprising an N-acetylgalactosamine (GaINAc) is conjugated to at least one strand of the dsRNA agent.