An array substrate, a manufacturing method of the array substrate, and a touch display device are provided. Orthographic projections of the touch signal lines (Tx) adjacent to each other included in a same touch signal line group (TxG) on the base substrate (BS) are respectively provided on two sides of an orthographic projection of a same second signal line (41) on the base substrate (BS), each of the orthographic projections of the touch signal lines (Tx) adjacent to each other and the orthographic projection of the same second signal line (41) includes a portion provided between orthographic projections of the touch electrodes (11) adjacent to each other on the base substrate (BS), and a layer in which the touch signal lines (Tx) adjacent to each other are provided is different from a layer in which the same second signal line (41) is provided.