- 专利标题： TGFßR2 EXTRACELLULAR DOMAIN TRUNCATED MOLECULE, FUSION PROTEIN OF TGFßR2 EXTRACELLULAR DOMAIN TRUNCATED MOLECULE AND ANTI-EGFR ANTIBODY, AND ANTI-TUMOR USE OF FUSION PROTEIN
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申请号： EP21796635.7申请日： 2021-04-26
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公开(公告)号： EP4144764A1公开(公告)日： 2023-03-08
- 发明人: XIE, Liangzhi , SUN, Chunyun , GUO, Erhong
- 申请人： Sinocelltech Ltd.
- 申请人地址： CN Beijing 100176 No.31 Kechuang 7th St, BDA
- 代理机构： Dolphin, Kirsty Mairi
- 优先权： CN202010351280 20200428
- 国际公布： WO2021218883 20211104
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/71 ; C07K14/495 ; A61K38/17 ; A61P35/00
摘要：
Provided are multiple types of TGFβR2 in truncated forms and a fusion protein constructed by TGFβR2 and EGFR antibody HPA8; also provided are a nucleic acid (comprising heavy/light chain variable regions) encoding the antibody, a vector, a pharmaceutical composition, and a kit comprising the nucleic acid; further provided is a fusion protein of the prepared truncated TGFβR2 receptor protein and a targeted EGFR and other multiple types of tumor target antibodies.
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