Embodiments of reduced pressure systems and methods for operating the systems are disclosed. In some embodiments, a system can include a source of negative pressure and a controller configured to present GUI screens for controlling and monitoring operation of the system. The controller can be configured to receive, via the GUI, an adjustment of a negative pressure therapy parameter and adjust (or cause adjustment) of the operation of the negative pressure source based on received adjustment. The controller can be further configured to record historical data parameters associated with negative pressure therapy parameters. The controller can also be configured to transmit (or cause transmission) over a communication channel at least some of recorded historical data. The system can be configured to provide external connectivity for accomplishing various activities, such as location tracking, compliance monitoring, tracking of operational data, remote selection and adjustment of therapy settings, etc.